MovDisordV3, France, Analysis, bibRecord, 000444

Two‐year follow‐up of subthalamic deep brain stimulation in Parkinson's disease

Identifieur interne : 000444 ( France/Analysis ); précédent : 000443; suivant : 000445

Two‐year follow‐up of subthalamic deep brain stimulation in Parkinson's disease

Auteurs : Jan Herzog [Allemagne] ; Jens Volkmann [Allemagne] ; Paul Krack [Allemagne, France] ; Florian Kopper [Allemagne] ; Monika Pötter [Allemagne] ; Delia Lorenz [Allemagne] ; Meike Steinbach [Allemagne] ; Stefan Klebe [Allemagne] ; Wolfgang Hamel [Allemagne] ; Bettina Schrader [Allemagne] ; Dieter Weinert [Allemagne] ; Dieter Müller [Allemagne] ; Hubertus M. Mehdorn [Allemagne] ; Günther Deuschl [Allemagne]

Source :

Movement Disorders [ 0885-3185 ] ; 2003-11.

RBID : ISTEX:D960A89B118AE86962E899A6027E0B6931A65902

Descripteurs français

Pascal (Inist)
- Bilatéral, Etude longitudinale, Evolution, Homme, Noyau sousthalamique, Parkinson maladie, Stimulation instrumentale, Traitement.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Bilateral, Electric Stimulation (instrumentation), Evolution, Female, Follow up study, Follow-Up Studies, Human, Humans, Instrumental stimulation, Male, Middle Aged, Parkinson Disease (diagnosis), Parkinson Disease (therapy), Parkinson disease, Severity of Illness Index, Subthalamic Nucleus (physiology), Subthalamic nucleus, Treatment, deep brain stimulation, subthalamic nucleus.
MESH :
- diagnosis : Parkinson Disease.
- instrumentation : Electric Stimulation.
- physiology : Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Female, Follow-Up Studies, Humans, Male, Middle Aged, Severity of Illness Index.

Abstract

We studied 48 patients after bilateral subthalamic nucleus deep brain stimulation (STN‐DBS) who were evaluated 6 months after the surgical procedure using the Unified Parkinson's Disease Rating Scale (UPDRS) in a standardized levodopa test. Additional follow‐up was available in 32 patients after 12 months and in 20 patients after 24 months. At 6 months follow‐up, STN‐DBS reduced the UPDRS motor score by 50.9% compared to baseline. This improvement remained constant at 12 months with 57.5% and at 24 months with 57.3%. Relevant side effects after STN‐DBS included intraoperative subdural hematoma without neurological sequelae (n = 1), minor intracerebral bleeding with slight transient hemiparesis (n = 1), dislocation of impulse generator (n = 2), transient perioperative confusional symptoms (n = 7), psychotic symptoms (n = 2), depression (n = 5), hypomanic behaviour (n = 2), and transient manic psychosis (n = 1). One patient died because of heart failure during the first postoperative year. The current series demonstrates efficacy and safety of STN‐DBS beyond the first year after surgical procedure. Complications of STN‐DBS comprise a wide range of psychiatric adverse events which, however, were temporary. © 2003 Movement Disorder Society

Url:

https://api.istex.fr/document/D960A89B118AE86962E899A6027E0B6931A65902/fulltext/pdf

DOI: 10.1002/mds.10518

Affiliations:

Links to Exploration step

ISTEX:D960A89B118AE86962E899A6027E0B6931A65902

Le document en format XML

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<author><name sortKey="Hamel, Wolfgang" sort="Hamel, Wolfgang" uniqKey="Hamel W" first="Wolfgang" last="Hamel">Wolfgang Hamel</name>
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<term>Follow up study</term>
<term>Follow-Up Studies</term>
<term>Human</term>
<term>Humans</term>
<term>Instrumental stimulation</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (therapy)</term>
<term>Parkinson disease</term>
<term>Severity of Illness Index</term>
<term>Subthalamic Nucleus (physiology)</term>
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<term>deep brain stimulation</term>
<term>subthalamic nucleus</term>
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<front><div type="abstract" xml:lang="en">We studied 48 patients after bilateral subthalamic nucleus deep brain stimulation (STN‐DBS) who were evaluated 6 months after the surgical procedure using the Unified Parkinson's Disease Rating Scale (UPDRS) in a standardized levodopa test. Additional follow‐up was available in 32 patients after 12 months and in 20 patients after 24 months. At 6 months follow‐up, STN‐DBS reduced the UPDRS motor score by 50.9% compared to baseline. This improvement remained constant at 12 months with 57.5% and at 24 months with 57.3%. Relevant side effects after STN‐DBS included intraoperative subdural hematoma without neurological sequelae (n = 1), minor intracerebral bleeding with slight transient hemiparesis (n = 1), dislocation of impulse generator (n = 2), transient perioperative confusional symptoms (n = 7), psychotic symptoms (n = 2), depression (n = 5), hypomanic behaviour (n = 2), and transient manic psychosis (n = 1). One patient died because of heart failure during the first postoperative year. The current series demonstrates efficacy and safety of STN‐DBS beyond the first year after surgical procedure. Complications of STN‐DBS comprise a wide range of psychiatric adverse events which, however, were temporary. © 2003 Movement Disorder Society</div>
</front>
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Movement Disorders (revue)

Two‐year follow‐up of subthalamic deep brain stimulation in Parkinson's disease

Two‐year follow‐up of subthalamic deep brain stimulation in Parkinson's disease

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Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

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Pour manipuler ce document sous Unix (Dilib)

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	Movement Disorders (revue)
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